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1957–1958 influenza pandemic

The 1957–1958 Asian flu pandemic was a global pandemic of influenza A virus subtype H2N2 that originated in Guizhou in Southern China.[3][4][1] The number of excess deaths caused by the pandemic is estimated to be 1–4 million around the world (1957–1958 and probably beyond), making it one of the deadliest pandemics in history.[1][2][5][6][7] A decade later, a reassorted viral strain H3N2 further caused the Hong Kong flu pandemic (1968–1969).[8]

1957–1958 influenza pandemic

Strains of A/H2N2

Worldwide

1957–1958

1–4 million (estimates) [1][2]

History[edit]

Origin and outbreak in China[edit]

The first cases were reported in Guizhou of southern China, in 1956[9][10] or in early 1957.[3][4][11][12] Observers within China noted an epidemic beginning in the third week of February in western Guizhou, between its capital Guiyang and the city of Qujing in neighbouring Yunnan province.[12] They were soon reported in Yunnan in late February or early March 1957.[12][13] By the middle of March, the flu had spread all over China.[12][14]


The People's Republic of China was not a member of the World Health Organization at the time (not until 1981[15]), and did not inform other countries about the outbreak.[14] The United States CDC, however, contradicting most records, states that the flu was "first reported in Singapore in February 1957".[16]


In late 1957, a second wave of the flu took place in Northern China, especially in rural areas.[14] In the same year, as response to the epidemic, the Chinese government established the Chinese National Influenza Center (CNIC), which soon published a manual on influenza in 1958.[14][17]

According to US CDC, two estimates of , 70,000 and 116,000, are provided.[16][157] The first estimate refers to the 1957–1958 flu season while the higher estimate is multi-year totals from 1957 to 1960.[158][159][160]

excess deaths

An estimated 33,000 deaths in the were attributed to the 1957–1958 flu outbreak.[9][143][161][162] The disease was estimated to have a 3% rate of complications and 0.3% mortality in the United Kingdom.[18]

United Kingdom

In , around 30,000 people died of the flu between September 1957 and April 1958.[163]

West Germany

According to the 2016 study in The Journal of Infectious Diseases, the highest excess mortality occurred in .[5]

Latin America

Economic effects[edit]

The Dow Jones Industrial Average lost 15% of its value in the second half of 1957, and the U.S. experienced a recession.[162] In the United Kingdom, the government paid out £10,000,000 in sickness benefit, and some factories and mines had to close.[18] Many schools had to close in Ireland, including seventeen in Dublin.[164]

Chowell G, Simonsen L, Fuentes R, Flores J, Miller MA, Viboud C (May 2017). . Influenza and Other Respiratory Viruses. 11 (3): 230–239. doi:10.1111/irv.12439. PMC 5410718. PMID 27883281.

"Severe mortality impact of the 1957 influenza pandemic in Chile"

Cobos AJ, Nelson CG, Jehn M, , Chowell G (2016). "Mortality and transmissibility patterns of the 1957 influenza pandemic in Maricopa County, Arizona". BMC Infectious Diseases. 16 (1): 405. doi:10.1186/s12879-016-1716-7. ISSN 1471-2334. PMC 4982429. PMID 27516082.

Viboud C