Katana VentraIP

Prokaryotic large ribosomal subunit

50S is the larger subunit of the 70S ribosome of prokaryotes, i.e. bacteria and archaea. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosomal RNA and 23S ribosomal RNA.

Despite having the same sedimentation rate, bacterial and archaeal ribosomes can be quite different.

Prokaryotic small ribosomal subunit (30S)

Ribosomal RNA

23S methyl RNA motif

http://pathmicro.med.sc.edu/mayer/antibiot.htm

https://web.archive.org/web/20110227235620/http://www.molgen.mpg.de/~ag_ribo/ag_franceschi/franceschi-projects-50S-antibiotics.html

https://web.archive.org/web/20080206051722/http://www.riboworld.com/antib/50santib-eng.shtml

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

23S+Ribosomal+RNA

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

5S+Ribosomal+RNA