8-Oxo-2'-deoxyguanosine
8-Oxo-2'-deoxyguanosine (8-oxo-dG) is an oxidized derivative of deoxyguanosine. 8-Oxo-dG is one of the major products of DNA oxidation.[1] Concentrations of 8-oxo-dG within a cell are a measurement of oxidative stress.
In aging[edit]
8-oxo-dG increases with age in DNA of mammalian tissues.[8] 8-oxo-dG increases in both mitochondrial DNA and nuclear DNA with age.[9] Fraga et al.[10] estimated that in rat kidney, for every 54 residues of 8-oxo-dG repaired, one residue remains unrepaired. (See also DNA damage theory of aging.)