Pre-recorded from Nashville, Tennessee

Pre-recorded from Tennessee State University

Megan Thee Stallion was originally planning to perform with BTS on "Butter", but pulled out "due to an unexpected personal matter".^[15][14]

– main show host

– presented Latin Album

& Rachel Zegler – presented Favorite Artist – Rock

– "coming up"

– presented Pop Duo/Group

– "coming up" (multiple segments)

– presented Pop Album

– presented Favorite Song – Hip-Hop

– introduced performance by Chlöe

– presented Favorite Song – Pop

– presented Favorite Trending Song

– presented Artist of the Year

– presented Favorite Female Artist – Latin

– presented New Artist of the Year

– introduced performance by Zoe Wees