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Anatomical Therapeutic Chemical Classification System

The Anatomical Therapeutic Chemical (ATC) Classification System is a drug classification system that classifies the active ingredients of drugs according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties. Its purpose is an aid to monitor drug use and for research to improve quality medication use. It does not imply drug recommendation or efficacy.[1] It is controlled by the World Health Organization Collaborating Centre for Drug Statistics Methodology (WHOCC), and was first published in 1976.[2][3][4]

History[edit]

The ATC system is based on the earlier Anatomical Classification System, which is intended as a tool for the pharmaceutical industry to classify pharmaceutical products (as opposed to their active ingredients).[7] This system, confusingly also called ATC, was initiated in 1971 by the European Pharmaceutical Market Research Association (EphMRA) and is being maintained by the EphMRA and Intellus. Its codes are organised into four levels.[8] The WHO's system, having five levels, is an extension and modification of the EphMRA's. It was first published in 1976.[2]

Other ATC classification systems[edit]

ATCvet[edit]

The Anatomical Therapeutic Chemical Classification System for veterinary medicinal products (ATCvet) is used to classify veterinary drugs. ATCvet codes can be created by placing the letter Q in front of the ATC code of most human medications. For example, furosemide for veterinary use has the code QC03CA01.


Some codes are used exclusively for veterinary drugs, such as QI Immunologicals, QJ51 Antibacterials for intramammary use or QN05AX90 amperozide.[12]

Herbal ATC (HATC)[edit]

The Herbal ATC system (HATC) is an ATC classification of herbal substances; it differs from the regular ATC system by using 4 digits instead of 2 at the 5th level group.[13]


The herbal classification is not adopted by WHO. The Uppsala Monitoring Centre is responsible for the Herbal ATC classification, and it is part of the WHODrug Global portfolio available by subscription.[14]

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Adaptations and updates[edit]

National issues of the ATC classification, such as the German Anatomisch-therapeutisch-chemische Klassifikation mit Tagesdosen, may include additional codes and DDDs not present in the WHO version.[16]


ATC follows guidelines[17] in creating new codes for newly approved drugs. An application is submitted to WHO for ATC classification and DDD assignment. A preliminary or temporary code is assigned and published on the website and in the WHO Drug Information for comment or objection. New ATC/DDD codes are discussed at the semi-annual Working Group meeting. If accepted it becomes a final decision and published semi-annually on the website and WHO Drug Information and implemented in the annual print/on-line ACT/DDD Index on January 1.[18]


Changes to existing ATC/DDD follow a similar process to become temporary codes and if accepted become a final decision as ATC/DDD alterations. ATC and DDD alterations are only valid and implemented in the coming annual updates; the original codes must continue until the end of the year.


An updated version of the complete on-line/print ATC index with DDDs is published annually on January 1.[19]

(CPR)

Classification of Pharmaco-Therapeutic Referrals

International Classification of Diseases

ICD-10

(ICPC-2) / ICPC-2 PLUS

International Classification of Primary Care

Medical classification

Pharmaceutical care

Pharmacotherapy

RxNorm

Official website

. World Health Organization. Retrieved 22 June 2021. Quarterly journal providing an overview of topics relating to medicines development and regulation.

"Who Drug Information"

(PDF). Family Medicine Research Centre. Archived (PDF) from the original on 2022-10-09. from "Health classifications and terminologies - CAPS - Coding Atlas for Pharmaceutical Substances". Faculty of Medicine and Health University of Sydney. Retrieved 18 June 2021.

"ATC: Introduction - page 2 of CAPS"

EphMRA Anatomical Classification (ATC and NFC)

. R script to scrape the ATC data from the WHOCC website; contains link to download entire ATC tree.

atcd

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