HLA-DR7

HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products.

Disease associations[edit]

By serotype[edit]

DR7 is positively associated with psoriasis vulgaris.

By Allele group[edit]

DRB1*07 is linked to T. cruzi infection with cardiomyopathy (also called Chaga's cardiomyopathy).

By extended haplotype[edit]

DR7:DQA1*0201:DQB1*0202 is associated with Graves' disease.^[2]

DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα⁵β²) is the primary risk DQ isoform in celiac disease. DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk transhaplotype.

DR53-DR7 may be associated with sclerosis/lupus associated anti-apolipoprotein antibodies.