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Orthomyxoviridae

Orthomyxoviridae (from Greek ὀρθός, orthós 'straight' + μύξα, mýxa 'mucus')[1] is a family of negative-sense RNA viruses. It includes seven genera: Alphainfluenzavirus, Betainfluenzavirus, Gammainfluenzavirus, Deltainfluenzavirus, Isavirus, Thogotovirus, and Quaranjavirus. The first four genera contain viruses that cause influenza in birds (see also avian influenza) and mammals, including humans. Isaviruses infect salmon; the thogotoviruses are arboviruses, infecting vertebrates and invertebrates (such as ticks and mosquitoes).[2][3][4] The Quaranjaviruses are also arboviruses, infecting vertebrates (birds) and invertebrates (arthropods).

This article is about the virus family that contains seven genera. For specific information about the subfamily that affects humans, see Influenza.

The four genera of Influenza virus that infect vertebrates, which are identified by antigenic differences in their nucleoprotein and matrix protein, are as follows:

caused "Spanish flu" in 1918 and "Swine flu" in 2009.[36]

H1N1

caused "Asian Flu".

H2N2

caused "Hong Kong Flu".

H3N2

"avian" or "bird flu".[37]

H5N1

has unusual zoonotic potential.[38]

H7N7

infects pigs and humans.[39]

H1N2

H7N2, H7N3, H10N7.

H9N2

Viability and disinfection[edit]

Mammalian influenza viruses tend to be labile, but can survive several hours in mucus.[57] Avian influenza virus can survive for 100 days in distilled water at room temperature, and 200 days at 17 °C (63 °F). The avian virus is inactivated more quickly in manure, but can survive for up to two weeks in feces on cages. Avian influenza viruses can survive indefinitely when frozen.[57] Influenza viruses are susceptible to bleach, 70% ethanol, aldehydes, oxidizing agents, and quaternary ammonium compounds. They are inactivated by heat of 133 °F (56 °C) for minimum of 60 minutes, as well as by low pH <2.[57]

Influenza-like illness