Isopenicillin N synthase
Isopenicillin N synthase (IPNS) is a non-heme iron protein belonging to the 2-oxoglutarate (2OG)-dependent dioxygenases oxidoreductase family. This enzyme catalyzes the formation of isopenicillin N from δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (LLD-ACV).
isopenicillin N synthase
This reaction is a key step in the biosynthesis of penicillin and cephalosporin antibiotics.[1]
The active sites of most isopenicillin N synthases contain an iron ion.[2]
This enzyme is also called isopenicillin N synthetase.