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Pantetheine hydrolase

In enzymology, a pantetheine hydrolase (EC 3.5.1.92) is an enzyme that catalyzes the chemical reaction

Identifiers

3.5.1.92

IntEnz view

BRENDA entry

NiceZyme view

KEGG entry

metabolic pathway

profile

RCSB PDB PDBe PDBsum

articles

articles

articles

proteins

Thus, the two substrates of this enzyme are (R)-pantetheine and H2O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol.


This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantetheine amidohydrolase. Other names in common use include pantetheinase, vanin, and vanin-1. This enzyme participates in pantothenate and CoA biosynthesis.

Dupre S, Cavallini D (1979). "Purification and properties of pantetheinase from horse kidney". Vitamins and Coenzymes Part D. Methods in Enzymology. Vol. 62. pp. 262–7. :10.1016/0076-6879(79)62227-9. ISBN 978-0-12-181962-0. PMID 440106.

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Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D (1984). "Continuous spectrophotometric assay of pantetheinase activity". Anal. Biochem. 142 (1): 175–81. :10.1016/0003-2697(84)90534-7. PMID 6549111.

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Maras B, Barra D, Dupre S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. :10.1016/S0014-5793(99)01439-8. PMID 10567687.

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P; Galland, F; Bazin, H; Zakharyev, VM; Imhof, BA; Naquet, P (1996). . Immunity. 5 (5): 391–405. doi:10.1016/S1074-7613(00)80496-3. PMID 8934567.

"Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing"

Maras B, Dupre S, Naquet P, Galland F (2000). . FEBS Lett. 483 (2–3): 149–54. doi:10.1016/S0014-5793(00)02110-4. PMID 11042271.

"Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice"

Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. :10.1007/s002510100327. PMID 11491533.

doi

Pace HC, Brenner C (2001). . Genome Biol. 2 (1): REVIEWS0001. doi:10.1186/gb-2001-2-1-reviews0001. PMC 150437. PMID 11380987.

"The nitrilase superfamily: classification, structure and function"