Katana VentraIP

Protein synthesis inhibitor

A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.[1]

While a broad interpretation of this definition could be used to describe nearly any compound depending on concentration, in practice, it usually refers to compounds that act at the molecular level on translational machinery (either the ribosome itself or the translation factor),[2] taking advantages of the major differences between prokaryotic and eukaryotic ribosome structures.

inhibits bacterial DNA transcription into mRNA by inhibiting DNA-dependent RNA polymerase by binding its beta-subunit.

Rifamycin

is a powerful inhibitor of eukaryotic DNA transcription machinery.

alpha-Amanitin

[17]

Aminoglycosides

[17]

Tetracyclines

The following antibiotics bind to the 30S subunit of the ribosome:


The following antibiotics bind to the 50S ribosomal subunit:

Protein biosynthesis

Bacterial translation

Eukaryotic translation

Archaeal translation