Katana VentraIP

Protein targeting

Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell.[1][2][note 1] Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.[1][2] Information contained in the protein itself directs this delivery process.[2][3] Correct sorting is crucial for the cell; errors or dysfunction in sorting have been linked to multiple diseases.[2][4][5]

[30]

Mohr–Tranebjaerg syndrome

[37]

Zellweger syndrome

(ALD).

Adrenoleukodystrophy

Refsum disease

[43]

Parkinson's disease

atherosclerosis, obesity, and diabetes[4]

Hypercholesterolemia

Protein transport is defective in the following genetic diseases:

is a bioinformatics tool that searches protein sequence queries for a known protein targeting sequence motifs.

Minimotif Miner

predicts signal peptides based on a supplied primary sequence.

Phobius

predicts signal peptide cleavage sites.

SignalP

predicts the subcellular localization of proteins.

LOCtree

Bulk flow

COPI

COPII

Clathrin

LocDB

PSORTdb

Signal peptide

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Protein+Transport