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Théodore Nicolas Gobley

Théodore[1] (Nicolas) Gobley (French: [ɡɔblɛ]; 11 May 1811, in Paris – 1 September 1876, in Bagnères-de-Luchon, was the first to isolate and ultimately determine the chemical structure of lecithin, the first identified and characterized member of the phospholipids class. He was also a pioneer researcher in the study and analysis of the chemical components of brain tissues.

Théodore Gobley

11 May 1811 (1811-05-11)

Paris, France

1 September 1876(1876-09-01) (aged 65)

Biography and academic courses[edit]

Gobley's family originated from the small city Fulvy in the Yonne region, a very rural hilly area of Burgundy. His father had settled at the end of the 18th century as a wine broker in Paris, marrying a young lady in a family long established (since at least the beginning of the 17th century) in that trade in the capital city of France. That family, Boutron, was registered in the 17th and 18th centuries as one of the 12 suppliers of wines to the King's Court.


Wine trading had strong links with alcoholic distillation, some close kin of the Boutron family were indeed spirits distillers, and it is likely this environment that led Gobley to studies in chemistry and pharmacy.


Indeed, an historical study conducted in 1957 by P. et C. Chatagnon on the early steps of brain tissues chemical structure studies mentions that Gobley effected a stay as apprentice by one of his parents named Guerin, indicated as pharmacist (actually, his brother-in-law, Denis Guerin (1798–1888), pharmacist in Paris for a few years in the early 1830s, but more well known as mayor of the city of Fontainebleau during close to 30 years, from 1843 till 1871, and so far as known, not related to the Boutron family).


Whatever the initial lead, further on Gobley entered full grade studies in pharmacy and in the early 1830s attended courses delivered by one of the great figures of French pharmaceutical and chemistry arts of that time, Pierre Jean Robiquet, of whom he became a close collaborator, and ultimately his son-in-law, through marrying Laure Robiquet, one of the daughters of his master and mentor.


Robiquet (1780–1840), a long-standing professor at the Ecole de Pharmacie in Paris (since 1811) was a very prominent, respected and honoured player among the French chemists/pharmacists community of the first half of the 19th century: member of the "Société de Pharmacie" later on designated as the "Académie Nationale de Pharmacie" (1817), of which he was Secretary General then President, (1817 till his death) (see (http://www.shp-asso.org/)), member of the "Académie de Médecine" (1820), member of the Académie des Sciences, distinguished with the order of Légion d'Honneur, author of numerous studies and pioneering work in the research of complex molecules in natural bodies, either plants or animals, who had isolated such fundamentals products, as caffeine, cantharidin, and most of all the alizarin, a powerful and stable red dye that was to become one of the first dyes to be mass-produced through a pure chemical synthesis path.


Gobley qualified as a pharmacist in 1835, married Laure Robiquet in 1837, and established himself as pharmacist in Paris (60 rue du Bac; the place had been run down when Boulevard Saint Germain was opened some 30 years later); in parallel to his trade, in his personal lab he conducted his research, and followed a path very similar to that of his father-in–law (demised in 1840): he entered the Ecole de Pharmacie as professor in 1842 (he quit in 1847), became a member of the Académie Nationale de Pharmacie in 1843, of which he became president in 1861, and was admitted as a member of the Académie de Médecine that same year.


While conducting various works on a very diversified range of topics very much like most pharmacist/chemists of the 19th century, Gobley singled himself out by a somehow unique lifelong pursuit in the study of lipids in the living animals reign, whereby he demonstrated the universal presence of a fundamental substance, which he named lecithin, and the exact composition of which he pursued during thirty years.


Gobley was also a philanthropist, and he was involved in the management of a local administration office for the housing of poorer people in the "Département de la Seine" (today, the greater Paris area including districts 75, 78, 91, 92, 93, 94, 95).


One of Gobley's daughters married composer Paul Collin. Gobley died on 1 September 1876 in the Pyrenean thermal resort of "Bagnères-de-Luchon, where he was on a family trip. His burial place lies at "cimetière Montparnasse" in southern Paris.

margaric acid, for which he confirmed the chemical breakdown obtained by Mr Varentrapp, at the expense of the variant sustained by Michel

Eugène Chevreul

oleic acid, for which he confirmed the chemical breakdown obtained by Mr Michel

Eugène Chevreul

an acid containing phosphorus, that a very careful and delicate series of analyses led him to indisputably identify as

glycerophosphoric acid

Other research, investigations and discoveries[edit]

In parallel, Gobley developed a number of additional threads of research of a more mainstream type:


In cooperation with a French doctor, member of the Academie de Medecine, Jean-Léonard-Marie Poiseuille, he published some results on urea in blood and urine.


In liaison with his commitment in public health matters and institutions, he involved himself in various studies on toxics, human nutrition and health, and the safety of industrial processes: thus he successively investigated toxins in toadstools (Recherches chimiques sur les champignons vénéneux, 1856), medicinal real or supposed properties of diverse plants, herbs and preparations, toxicity of lead in widespread tins used for cooking utensils, poisonous effects of rye.


In the tradition of the methods of Robiquet, from the natural vanilla fruit, he obtained in 1858 the very first samples of pure vanillin, its active flavoring principle. Gobley lived just long enough to see this breakthrough bring about the advent of artificial industrial vanillin synthesis, in a process based on glycosides extracted from the sap of pine trees (1874), opening the path to the extraordinary expansion of the use of that very popular flavour. Incidentally that also brought about the complete collapse of the growing of natural vanilla and the related industry, but that was probably not intended by Gobley.

"Sur l'existence des acides oléique, margarique et phosphoglycérique dans le jaune d'oeuf. Premier Mémoire: Sur la composition chimique du jaune d'oeuf"; par M. Gobley. (Extrait). C R hebd Acad Sci 1845, 11, 8

66

Pierre Jean Robiquet

Eugène Chevreul

Louis-Nicolas Vauquelin

Théophile-Jules Pelouze

Edmond Frémy

Oscar Liebreich

Jean Léonard Marie Poiseuille

Strecker amino acid synthesis

Dossier de Légion d'Honneur (base LEONORE des Archives Nationales, cote L1157072)

Dossier biographique à la bibliothèque interuniversitaire de pharmacie

Eloge funèbre par Mr Jean Baptiste Chevallier (1793–1879), membre de l'Académie de Pharmacie

L'étude chimique des constituents du tissu cérébral au cours du XIXème siècle, Les pionniers français (III): Théodore-Nicolas GOBLEY (1811–1874),par Mlle C.Chatagnon et P.Chatagnon, extrait des Annales Médico-Psychologiques, n°2, juillet 1957

Bernard F. Szuhaj, "Lecithins", The American Oil Chemists Society, 1989

Richard L. Myers, Rusty L. Myers, "The 100 Most Important Chemical Compounds", Greenwood Publishing Group, 2007

Donald Bayley Tower, Michel-Augustin Thouret, "Brain Chemistry and the French Connection, 1791-1841: An Account of the Chemical Analyses of the Human Brain by Thouret", Raven Press, 1994

Adolf Strecker, "Isolement de la lécithine de l'oeuf" Académie de Münich, 1869, t2, 269

J.L.W Thudichum "Die chemische Konstitution des Gehirns des Menschen und der Tiere", Tübingen, Verlag von Franz Pietzcker, 1901

J.F. John, "Chemische Schriften, vol 4, n°31, p228

J.F. John, "Zoochemische Tabellen", T.I.A, 1814, p12

O. Liebreich, Ann.Chem., 1864,134,29

La Création de l'Ecole de Pharmacie (in French)

Académie Nationale de Pharmacie (in French)

Portrait of Robiquet at The Ecole de Pharmacie, Salle des actes (in French)

Fontainebleau streets denomination, origin (in French)