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Eating disorder

An eating disorder is a mental disorder defined by abnormal eating behaviors that adversely affect a person's physical or mental health.[1] Types of eating disorders include binge eating disorder, where the patient eats a large amount in a short period of time; anorexia nervosa, where the person has an intense fear of gaining weight and restricts food or overexercises to manage this fear; bulimia nervosa, where individuals eat a large quantity (binging) then try to rid themselves of the food (purging); pica, where the patient eats non-food items; rumination syndrome, where the patient regurgitates undigested or minimally digested food; avoidant/restrictive food intake disorder (ARFID), where people have a reduced or selective food intake due to some psychological reasons; and a group of other specified feeding or eating disorders.[1] Anxiety disorders, depression and substance abuse are common among people with eating disorders.[2] These disorders do not include obesity.[1] People often experience comorbidity between an eating disorder and OCD. It is estimated 20–60% of patients with an ED have a history of OCD.[9]

Eating disorder

Abnormal eating habits that negatively affect physical or mental health[1]

Anxiety disorders, depression, substance abuse,[2] arrhythmia, heart failure and other heart problems, acid reflux (gastroesophageal reflux disease or GERD), gastrointestinal problems, low blood pressure (hypotension), organ failure and brain damage, osteoporosis and tooth damage, severe dehydration and constipation, stopped menstrual cycles (amenorrhea), infertility, stroke[3]

Unclear[4]

Counseling, proper diet, normal amount of exercise, medications[2]

The causes of eating disorders are not clear, although both biological and environmental factors appear to play a role.[2][4] Cultural idealization of thinness is believed to contribute to some eating disorders.[4] Individuals who have experienced sexual abuse are also more likely to develop eating disorders.[7] Some disorders such as pica and rumination disorder occur more often in people with intellectual disabilities.[1]


Treatment can be effective for many eating disorders.[2] Treatment varies by disorder and may involve counseling, dietary advice, reducing excessive exercise, and the reduction of efforts to eliminate food.[2] Medications may be used to help with some of the associated symptoms.[2] Hospitalization may be needed in more serious cases.[2] About 70% of people with anorexia and 50% of people with bulimia recover within five years.[10] Only 10% of people with eating disorders receive treatment, and of those, approximately 80% do not receive the proper care. Many are sent home weeks earlier than the recommended stay and are not provided with the necessary treatment.[11] Recovery from binge eating disorder is less clear and estimated at 20% to 60%.[10] Both anorexia and bulimia increase the risk of death.[10] When people experience comorbidity with an eating disorder and OCD, certain aspects of treatment can be negatively impacted. OCD can make it harder to recover from obsession over weight and shape, body dissatisfaction, and body checking.[12] This is in part because ED cognitions serve a similar purpose to OCD obsessions and compulsions (e.g., safety behaviors as temporary relief from anxiety).[13] Research shows OCD does not have an impact on the BMI of patients during treatment.[12]


Estimates of the prevalence of eating disorders vary widely, reflecting differences in gender, age, and culture as well as methods used for diagnosis and measurement.[14][15][16] In the developed world, anorexia affects about 0.4% and bulimia affects about 1.3% of young women in a given year.[1] Binge eating disorder affects about 1.6% of women and 0.8% of men in a given year.[1] According to one analysis, the percent of women who will have anorexia at some point in their lives may be up to 4%, or up to 2% for bulimia and binge eating disorders.[10] Rates of eating disorders appear to be lower in less developed countries.[17] Anorexia and bulimia occur nearly ten times more often in females than males.[1] The typical onset of eating disorders is in late childhood to early adulthood.[2] Rates of other eating disorders are not clear.[1]

Classification[edit]

ICD and DSM diagnoses[edit]

These eating disorders are specified as mental disorders in standard medical manuals, including the ICD-10 and the DSM-5.

Aesthetic sports (dance, figure skating, gymnastics) – 35%

Weight dependent sports (judo, wrestling) – 29%

Endurance sports (cycling, swimming, running) – 20%

Technical sports (golf, high jumping) – 14%

Ball game sports (volleyball, soccer) – 12%

Biochemical

[189]

and ghrelin: leptin is a hormone produced primarily by the fat cells in the body; it has an inhibitory effect on appetite by inducing a feeling of satiety. Ghrelin is an appetite inducing hormone produced in the stomach and the upper portion of the small intestine. Circulating levels of both hormones are an important factor in weight control. While often associated with obesity, both hormones and their respective effects have been implicated in the pathophysiology of anorexia nervosa and bulimia nervosa.[204] Leptin can also be used to distinguish between constitutional thinness found in a healthy person with a low BMI and an individual with anorexia nervosa.[56][205]

Leptin

Gut bacteria and : studies have shown that a majority of patients with anorexia and bulimia nervosa have elevated levels of autoantibodies that affect hormones and neuropeptides that regulate appetite control and the stress response. There may be a direct correlation between autoantibody levels and associated psychological traits.[206][207] Later study revealed that autoantibodies reactive with alpha-MSH are, in fact, generated against ClpB, a protein produced by certain gut bacteria e.g. Escherichia coli. ClpB protein was identified as a conformational antigen-mimetic of alpha-MSH. In patients with eating disorders plasma levels of anti-ClpB IgG and IgM correalated with patients' psychological traits[208]

immune system

Infection: is an abbreviation for the controversial Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections hypothesis. Children with PANDAS are postulated to "have obsessive-compulsive disorder (OCD) and/or tic disorders such as Tourette syndrome, and in whom symptoms worsen following infections such as strep throat". (NIMH) PANDAS and the broader PANS are hypothesized to be a precipitating factor in the development of anorexia nervosa in some cases, (PANDAS AN).[209][210][211]

PANDAS

: studies have shown that lesions to the right frontal lobe or temporal lobe can cause the pathological symptoms of an eating disorder.[212][213][214]

Lesions

: tumors in various regions of the brain have been implicated in the development of abnormal eating patterns.[215][216][217][218][219]

Tumors

Brain : a study highlights a case in which prior calcification of the right thalumus may have contributed to development of anorexia nervosa.[220]

calcification

: is the representation of the body located in the somatosensory cortex, first described by renowned neurosurgeon Wilder Penfield. The illustration was originally termed "Penfield's Homunculus", homunculus meaning little man. "In normal development this representation should adapt as the body goes through its pubertal growth spurt. However, in AN it is hypothesized that there is a lack of plasticity in this area, which may result in impairments of sensory processing and distortion of body image". (Bryan Lask, also proposed by VS Ramachandran)

somatosensory homunculus

complications: There have been studies done which show maternal smoking, obstetric and perinatal complications such as maternal anemia, very pre-term birth (less than 32 weeks), being born small for gestational age, neonatal cardiac problems, preeclampsia, placental infarction and sustaining a cephalhematoma at birth increase the risk factor for developing either anorexia nervosa or bulimia nervosa. Some of this developmental risk as in the case of placental infarction, maternal anemia and cardiac problems may cause intrauterine hypoxia, umbilical cord occlusion or cord prolapse may cause ischemia, resulting in cerebral injury, the prefrontal cortex in the fetus and neonate is highly susceptible to damage as a result of oxygen deprivation which has been shown to contribute to executive dysfunction, ADHD, and may affect personality traits associated with both eating disorders and comorbid disorders such as impulsivity, mental rigidity and obsessionality. The problem of perinatal brain injury, in terms of the costs to society and to the affected individuals and their families, is extraordinary. (Yafeng Dong, PhD)[221][222][223][224][225][226][227][228][229][230][231]

Obstetric

Symptom of : Evidence suggests that the symptoms of eating disorders are actually symptoms of the starvation itself, not of a mental disorder. In a study involving thirty-six healthy young men that were subjected to semi-starvation, the men soon began displaying symptoms commonly found in patients with eating disorders.[203][232] In this study, the healthy men ate approximately half of what they had become accustomed to eating and soon began developing symptoms and thought patterns (preoccupation with food and eating, ritualistic eating, impaired cognitive ability, other physiological changes such as decreased body temperature) that are characteristic symptoms of anorexia nervosa.[203] The men used in the study also developed hoarding and obsessive collecting behaviors, even though they had no use for the items, which revealed a possible connection between eating disorders and obsessive–compulsive disorder.[203]

starvation

is known as the "great imitator", as it may present as a variety of psychiatric or neurological disorders including anorexia nervosa.[249][250]

Lyme disease

,[6] such as celiac disease, Crohn's disease, peptic ulcer, eosinophilic esophagitis[106] or non-celiac gluten sensitivity,[251] among others. Celiac disease is also known as the "great imitator", because it may involve several organs and cause an extensive variety of non-gastrointestinal symptoms, such as psychiatric and neurological disorders,[252][253][254] including anorexia nervosa.[106]

Gastrointestinal diseases

is a disorder of the adrenal cortex which results in decreased hormonal production. Addison's disease, even in subclinical form may mimic many of the symptoms of anorexia nervosa.[255]

Addison's disease

is one of the most common forms of cancer in the world. Complications due to this condition have been misdiagnosed as an eating disorder.[256]

Gastric adenocarcinoma

hyperthyroidism, hypoparathyroidism and hyperparathyroidism may mimic some of the symptoms of, can occur concurrently with, be masked by or exacerbate an eating disorder.[257][258][259][260][261][262][263][264]

Hypothyroidism

seropositivity: even in the absence of symptomatic toxoplasmosis, toxoplasma gondii exposure has been linked to changes in human behavior and psychiatric disorders including those comorbid with eating disorders such as depression. In reported case studies the response to antidepressant treatment improved only after adequate treatment for toxoplasma.[265]

Toxoplasma

: It is estimated that there may be up to one million cases of untreated syphilis in the US alone. "The disease can present with psychiatric symptoms alone, psychiatric symptoms that can mimic any other psychiatric illness". Many of the manifestations may appear atypical. Up to 1.3% of short term psychiatric admissions may be attributable to neurosyphilis, with a much higher rate in the general psychiatric population. (Ritchie, M Perdigao J,)[266]

Neurosyphilis

: a wide variety of autonomic nervous system (ANS) disorders may cause a wide variety of psychiatric symptoms including anxiety, panic attacks and depression. Dysautonomia usually involves failure of sympathetic or parasympathetic components of the ANS system but may also include excessive ANS activity. Dysautonomia can occur in conditions such as diabetes and alcoholism.

Dysautonomia

Emotional Bites: a simple way to discuss emotional eating is to ask children about why they might eat besides being hungry. Talk about more effective ways to cope with emotions, emphasizing the value of sharing feelings with a trusted adult.

[275]

Say No to Teasing: another concept is to emphasize that it is wrong to say hurtful things about other people's body sizes.

[276]

Body Talk: emphasize the importance of listening to one's body. That is, eating when you are hungry (not starving) and stopping when you are satisfied (not stuffed). Children intuitively grasp these concepts.

[275]

Fitness Comes in All Sizes: educate children about the genetics of body size and the normal changes occurring in the body. Discuss their fears and hopes about growing bigger. Focus on fitness and a balanced diet.[278]

[277]

Prevention aims to promote a healthy development before the occurrence of eating disorders. It also intends early identification of an eating disorder before it is too late to treat. Children as young as ages 5–7 are aware of the cultural messages regarding body image and dieting.[274] Prevention comes in bringing these issues to the light. The following topics can be discussed with young children (as well as teens and young adults).


Internet and modern technologies provide new opportunities for prevention. Online programs have the potential to increase the use of prevention programs.[279] The development and practice of prevention programs via online sources make it possible to reach a wide range of people at minimal cost.[280] Such an approach can also make prevention programs to be sustainable.


Parents can do a lot for their children at a young age to impede them from ever seeing themselves in the eyes of an eating disorder. The parents who are actively engaged in their children's lives' often contribute to fostering a stronger sense of self-love in them.

Cognitive behavioral therapy

[282]

The Maudsley anorexia nervosa treatment for adults (MANTRA), which focuses on addressing rigid information processing styles, emotional avoidance, pro-anorectic beliefs, and difficulties with interpersonal relationships.[295] These four targets of treatment are proposed to be core maintenance factors within the Cognitive-Interpersonal Maintenance Model of anorexia nervosa.[296]

[282]

[282][297]

Dialectical behavior therapy

[282][298] including "conjoint family therapy" (CFT), "separated family therapy" (SFT) and Maudsley Family Therapy.[299][300]

Family therapy

: focuses on gaining control and changing unwanted behaviors.[282][301]

Behavioral therapy

(IPT)[282][302]

Interpersonal psychotherapy

(CEBT)[303]

Cognitive Emotional Behaviour Therapy

[304]

Art therapy

Nutrition counseling and Medical nutrition therapy[306][307][308]

[305]

and guided self-help have been shown to be helpful in AN, BN and BED;[288][309][310][311] this includes support groups and self-help groups such as Eating Disorders Anonymous and Overeaters Anonymous.[312][313] Having meaninful relationships are often a way to recovery. Having a partner, friend or someone else close in your life may lead away from the way of problematic eating according to professor Cynthia M. Bulik.[314]

Self-help

[282]

psychoanalytic psychotherapy

Inpatient care

: Pregnant women with a binge eating disorder have shown to have a greater chance of having a miscarriage compared to pregnant women with any other eating disorders. According to a study done, out of a group of pregnant women being evaluated, 46.7% of the pregnancies ended with a miscarriage in women that were diagnosed with BED, with 23.0% in the control. In the same study, 21.4% of women diagnosed with Bulimia Nervosa had their pregnancies end with miscarriages and only 17.7% of the controls.[341]

Miscarriages

: An individual who is in remission from BN and EDNOS (Eating Disorder Not Otherwise Specified) is at a high risk of falling back into the habit of self-harm. Factors such as high stress regarding their job, pressures from society, as well as other occurrences that inflict stress on a person, can push a person back to what they feel will ease the pain. A study tracked a group of selected people that were either diagnosed with BN or EDNOS for 60 months. After the 60 months were complete, the researchers recorded whether or not the person was having a relapse. The results found that the probability of a person previously diagnosed with EDNOS had a 41% chance of relapsing; a person with BN had a 47% chance.[342]

Relapse

: People who are showing signs of attachment anxiety will most likely have trouble communicating their emotional status as well as having trouble seeking effective social support. Signs that a person has adopted this symptom include not showing recognition to their caregiver or when he/she is feeling pain. In a clinical sample, it is clear that at the pretreatment step of a patient's recovery, more severe eating disorder symptoms directly corresponds to higher attachment anxiety. The more this symptom increases, the more difficult it is to achieve eating disorder reduction prior to treatment.[343]

Attachment insecurity

Impaired Decision Making: Studies have found mixed results on the relationship between eating disorders and decision making. Researchers have continuously found that patients with anorexia were less capable of thinking about long-term consequences of their decisions when completing the Iowa Gambling Task, a test designed to measure a person's decision-making capabilities. Consequently, they were at a higher risk of making hastier, harmful choices.

[344]

Since 2017, the number of cost-effectiveness studies regarding eating disorders appears to be increasing in the past six years.

[356]

In 2011 United States dollars, annual healthcare costs were $1,869 greater among individuals with eating disorders compared to the general population. The added presence of mental health comorbidities was also associated with higher, but not statistically significant, costs difference of $1,993.[357]

[357]

In 2013 Canadian dollars, the total hospital cost per admission for treatment of anorexia nervosa was $51,349 and the total societal cost was $54,932 based on an average length of stay of 37.9 days. For every unit increase in body mass index, there was also a 15.7% decrease in hospital cost.[358]

[358]

For Ontario, Canada patients who received specialized inpatient care for an eating disorder both out of country and in province, annual total healthcare costs were about $11 million before 2007 and $6.5 million in the years afterwards. For those treated out of country alone, costs were about $5 million before 2007 and $2 million in the years afterwards.[359]

[359]

Evolutionary perspective[edit]

Evolutionary psychiatry as an emerging scientific discipline has been studying mental disorders from an evolutionary perspective. If eating disorders have evolutionary functions or if they are new modern "lifestyle" problems is still debated.[360][361][362]

Eating disorders in Chinese women

Eating disorder not otherwise specified

Fatphobia

Feeding disorder

at Curlie

Eating disorder