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Federal Food, Drug, and Cosmetic Act of 1938

The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C) is a set of laws passed by the United States Congress in 1938 giving authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of food, drugs, medical devices, and cosmetics. The FDA's principal representative with members of congress during its drafting was Charles W. Crawford.[2] A principal author of this law was Royal S. Copeland, a three-term U.S. senator from New York.[3] In 1968, the Electronic Product Radiation Control provisions were added to the FD&C. Also in that year the FDA formed the Drug Efficacy Study Implementation (DESI) to incorporate into FD&C regulations the recommendations from a National Academy of Sciences investigation of effectiveness of previously marketed drugs.[4] The act has been amended many times, most recently to add requirements about bioterrorism preparations.

Long title

To prohibit the movement in interstate commerce of adulterated and misbranded food, drugs, devices, and cosmetics, and for other purposes.

FFDCA, FD&C Act

21 U.S.C. ch. 9 § 301 et seq.

The introduction of this act was influenced by the death of more than 100 patients due to elixir sulfanilamide, a sulfanilamide medication where the toxic solvent diethylene glycol was used to dissolve the drug and make a liquid form.[5] It replaced the earlier Pure Food and Drug Act of 1906.

Homeopathic medications[edit]

Homeopathic preparations are regulated and protected under Sections 201(g) and 201(j), provided that such medications are formulated from substances listed in the Homeopathic Pharmacopoeia of the United States, which the Act recognizes as an official drug compendium.[16]


However, under separate authority of FTC Act, the Federal Trade Commission declared in November 2016 that homeopathic products cannot include claims of effectiveness without "competent and reliable scientific evidence". If no such evidence exists, they must state this fact clearly on their labeling.[17]

Bottled water[edit]

Bottled water is regulated by the FDA as a food. The Agency has published identity standards for types of water (mineral water, spring water), and regulations covering water processing and bottling, water quality and product labeling.[18][19][20]

Cosmetics[edit]

This Act defines cosmetics as "articles intended to be rubbed, poured, sprinkled, or sprayed on, introduced into, or otherwise applied to the human body ... for cleansing, beautifying, promoting attractiveness, or altering the appearance." Under the Act, the FDA does not approve cosmetic products, but the Act prohibits the marketing of adulterated or misbranded cosmetics.[21] However, the FDA does not have the authority to order recalls of cosmetics.[22][23] If a company is selling a product that is adulterated or misbranded, the FDA can ask the company to recall their product or sue them.[21] The FDA can and does inspect cosmetics manufacturing facilities to ensure that cosmetics are not adulterated.[21]

Class I: Devices that do not require premarket approval or clearance but must follow general controls. is a class I device.

Dental floss

Class II: Devices that are cleared using the 510(k) process. Diagnostic tests, cardiac catheters, hearing aids, and are examples of class II devices.

dental amalgams

Class III: Devices that are approved by the premarket approval (PMA) process, analogous to a . These tend to be devices that are permanently implanted into a human body or may be necessary to sustain life. An artificial heart meets both criteria. The most commonly recognized class III device is an automated external defibrillator. Devices that do not meet either criterion are generally cleared as class II devices.

New Drug Application

Related legislation[edit]

The Wheeler-Lea Act, passed in 1938, granted the Federal Trade Commission the authority to oversee advertising of all products regulated by FDA, other than prescription drugs.

Public Law (PL) 82–215 (October 26, 1951) created prescription-only status for some drugs

Durham-Humphrey Amendment

Drug Efficacy Amendment ("") PL 87–781 (October 10, 1962)

Kefauver Harris Amendment

Vitamin-Mineral Amendment ("") (April 22, 1976) prohibited the FDA from establishing standards to limit the potency of vitamins and minerals in food supplements or regulating them as drugs based solely on their potency.[35]

Proxmire Amendment

Drug Abuse Control Amendments of 1965

PL 94–295 (May 28, 1976)

Medical Device Amendments of 1976

PL 96–359 (October 26, 1980)

Infant Formula Act of 1980

PL 97–414 (January 4, 1983)

Orphan Drug Act

PL 98–417 (aka Hatch-Waxman) (September 24, 1984)

Drug Price Competition and Patent Term Restoration Act of 1984

PL 100–293 (August 18, 1988)

Prescription Drug Marketing Act of 1987

PL 100–670 (November 16, 1988)

Generic Animal Drug and Patent Term Restoration Act of 1988

PL 101–535 (November 8, 1990)

Nutrition Labeling and Education Act of 1990

PL 101–629 (November 28, 1990)

Safe Medical Device Amendments of 1990

PL 102–300 (June 16, 1992)

Medical Device Amendments of 1992

(PDUFA) of 1992, PL 102–571 (October 29, 1992)

Prescription Drug User Fee Act

(AMDUCA) of 1994, PL 103–396 (October 22, 1994)

Animal Medicinal Drug Use Clarification Act

PL 103–417 (October 25, 1994)

Dietary Supplement Health And Education Act of 1994

PL 104–170 (August 3, 1996)

Food Quality Protection Act of 1996

PL 104–250 (October 9, 1996)

Animal Drug Availability Act of 1996

PL 107–109 (January 4, 2002)

Best Pharmaceuticals for Children Act

(MDUFMA) of 2002, PL 107–250 (October 26, 2002)

Medical Device User Fee and Modernization Act

PL 108–130 (February 20, 2003)

Animal Drug User Fee Act of 2003

PL 108–155 (December 3, 2003)

Pediatric Research Equity Act of 2003

PL 108–282 (August 2, 2004)[36]

Minor Use and Minor Species Animal Health Act of 2004

PL 108–282 (August 2, 2004)

Food Allergen Labeling and Consumer Protection Act of 2004

(January 4, 2011)

FDA Food Safety Modernization Act

Generic Drug User Fee Amendment of 2012

[37]

PL 114–255 (December 13, 2016)[38][39][40]

21st Century Cures Act

PL 115–52 (August 18, 2017)[41]

FDA Reauthorization Act of 2017

Descriptions of these can be found at the FDA's web site.[34]


Amendments:


Other laws:[42]

California Safe Cosmetics Act of 2005

Some US states have adopted the FD&C Act as an equivalent state law and will by default adopt any changes to the Federal law as changes to the state law as well.

Drugs in the United States

Food Administration

Food Quality Protection Act

Kefauver Harris Amendment

List of food additives

Office of Criminal Investigations

Pure Food and Drug Act

Regulation of therapeutic goods

(c. 1933 book which influenced passage of this Act)

100,000,000 Guinea Pigs

of the United States Code from the LII

As codified in 21 U.S.C. chapter 9

of the United States Code from the US House of Representatives

As codified in 21 U.S.C. chapter 9

(PDF/details) as amended in the GPO Statute Compilations collection

Federal Food, Drug, and Cosmetic Act

Color Additive Status List

Food Ingredients and Colors

at the FDA

Information on Releasable 510(k)s