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National Institutes of Health

The National Institutes of Health, commonly referred to as NIH, is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.

"NIH" redirects here. For other uses, see NIH (disambiguation).

As of 2013, the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world,[1] while, as of 2003, the extramural arm provided 28% of biomedical research funding spent annually in the U.S., or about US$26.4 billion.[2]


The NIH comprises 27 separate institutes and centers of different biomedical disciplines and is responsible for many scientific accomplishments, including the discovery of fluoride to prevent tooth decay, the use of lithium to manage bipolar disorder, and the creation of vaccines against hepatitis, Haemophilus influenzae (HIB), and human papillomavirus (HPV).[3]


In 2019, the NIH was ranked number two in the world, behind Harvard University, for biomedical sciences in the Nature Index, which measured the largest contributors to papers published in a subset of leading journals from 2015 to 2018.[4][5]

Office of AIDS Research

Office of Research on Women's Health

Office of Disease Prevention

Sexual and Gender Minority Research Office

Tribal Health Research Office

Office of Program Evaluation and Performance

The NIH Office of the Director is the central office responsible for setting policy for NIH, and for planning, managing, and coordinating the programs and activities of all NIH components. The NIH Director plays an active role in shaping the agency's activities and outlook. The Director is responsible for providing leadership to the Institutes and Centers by identifying needs and opportunities, especially in efforts involving multiple Institutes.[18] Within the Director's Office is the Division of Program Coordination, Planning and Strategic Initiatives with 12 divisions including:


The Agency Intramural Research Integrity Officer "is directly responsible for overseeing the resolution of all research misconduct allegations involving intramural research, and for promoting research integrity within the NIH Office of Intramural Research (OIR)."[19] There is a Division of Extramural Activities, which has its own Director.[20] The Office of Ethics has its own Director,[21] as does the Office of Global Research.[22]

1908: 's discovery that rodents were a reservoir of bubonic plague.

George W. McCoy

1911: George W. McCoy, Charles W. Chapin, William B. Wherry, and B. H. Lamb described the previously unknown .

tularemia

1924: Roscoe R. Spencer and Ralph R. Parker developed a vaccine against .

Rocky Mountain spotted fever

1930: developed a treatment for mercury poisoning used widely before the development of dimercaptoethanol.

Sanford M. Rosenthal

1943: Wilton R. Earle pioneered the process and published a paper describing the production of malignancy in vitro, Katherine K. Sanford developed the first clone from an isolated cancer cell, and Virginia J. Evans devised a medium that supported growth of cells in vitro.

cell culture

1940s–1950s: and colleagues described the pentose phosphate pathway.

Bernard Horecker

1950s: discovered a new class of enzymes, cytochrome P450 monooxygenases, a fundamental of drug metabolism.

Julius Axelrod

1950: discovered phosphotransacetylose, elucidating the role of acetyl CoA in fatty acid metabolism.

Earl Stadtman

1960s: Discovered the first human slow virus disease, kuru, which is a degenerative, fatal infection of the central nervous system. This discovery of a new mechanism for infectious diseases revolutionized thinking in and neurology.

microbiology

1960s: Defined the mechanisms that regulate noradrenaline, one of the most important neurotransmitters in the brain.

1960s: Developed the first licensed rubella vaccine and the first test for rubella antibodies for large scale testing.

1960s: Developed an effective combination drug regimen for .

Hodgkin's lymphoma

1960s: Discovery that tooth decay is caused by bacteria.

1970s: Developed the assay for that evolved into the home pregnancy tests.

human chorionic gonadotropin

1970s: Described the hormonal cycle involved in menstruation.

1980s: Determined the complete structure of the that is involved in allergic reactions.

IgE receptor

1990s: First trial of in humans.

gene therapy

Commercial partnerships[edit]

In 2011 and 2012, the Department of Health and Human Services Office of Inspector General published a series of audit reports revealing that throughout the fiscal years 2000–2010, institutes under the aegis of the NIH did not comply with the time and amount requirements specified in appropriations statutes, in awarding federal contracts to commercial partners, committing the federal government to tens of millions of dollars of expenditure ahead of appropriation of funds from Congress.[73]

List of institutes and centers of the National Institutes of Health

United States Public Health Service

Foundation for the National Institutes of Health

National Institutes of Health Stroke Scale

Heads of International Research Organizations

NIH Toolbox

National Institute of Food and Agriculture

(BEIP)

Biomedical Engineering and Instrumentation Program

Public Domain This article incorporates from websites or documents of the National Institutes of Health.

public domain material

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Official website

in the Federal Register

National Institutes of Health

Collection of information on NIH's Regional Medical Programs, from the National Library of Medicine

Regional Medical Programs

Collection of information on NIH's Regional Medical Programs, from the National Library of Medicine

Regional Medical Programs