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Evolutionary physiology

Evolutionary physiology is the study of the biological evolution of physiological structures and processes; that is, the manner in which the functional characteristics of organisms have responded to natural selection or sexual selection or changed by random genetic drift across multiple generations during the history of a population or species.[2] It is a sub-discipline of both physiology and evolutionary biology. Practitioners in the field come from a variety of backgrounds, including physiology, evolutionary biology, ecology, and genetics.

Accordingly, the range of phenotypes studied by evolutionary physiologists is broad, including life history traits, behavior, whole-organism performance,[3][4] functional morphology, biomechanics, anatomy, classical physiology, endocrinology, biochemistry, and molecular evolution. The field is closely related to comparative physiology, ecophysiology, and environmental physiology, and its findings are a major concern of evolutionary medicine. One definition that has been offered is "the study of the physiological basis of fitness, namely, correlated evolution (including constraints and trade-offs) of physiological form and function associated with the environment, diet, homeostasis, energy management, longevity, and mortality and life history characteristics".[5]

History[edit]

As the name implies, evolutionary physiology is the product of a merger between two distinct scientific disciplines. According to Garland and Carter,[2] evolutionary physiology arose in the late 1970s, following debates concerning the metabolic and thermoregulatory status of dinosaurs (see physiology of dinosaurs) and mammal-like reptiles.


This period was followed by attempts in the early 1980s to integrate quantitative genetics into evolutionary biology, which had spillover effects on other fields, such as behavioral ecology and ecophysiology. In the mid- to late 1980s, phylogenetic comparative methods started to become popular in many fields, including physiological ecology and comparative physiology. A 1987 volume titled New Directions in Ecological Physiology[6] had little ecology[7] but a considerable emphasis on evolutionary topics. It generated vigorous debate, and within a few years the National Science Foundation had developed a panel titled Ecological and Evolutionary Physiology.


Shortly thereafter, selection experiments and experimental evolution became increasingly common in evolutionary physiology. Macrophysiology has emerged as a sub-discipline, in which practitioners attempt to identify large-scale patterns in physiological traits (e.g. patterns of co-variation with latitude) and their ecological implications.[8] [9] [10]


More recently, the importance of evolutionary physiology has been argued from the perspective of functional analyses, epigenetics, and an extended evolutionary synthesis.[11] The growth of evolutionary physiology is also reflected in the emergence of sub-disciplines, such as evolutionary biomechanics[12][13] and evolutionary endocrinology,[14][15] which addresses such hybrid questions as "What are the most common endocrine mechanisms that respond to selection on behavior or life-history traits?"[16]

Emergent properties[edit]

As a hybrid scientific discipline, evolutionary physiology provides some unique perspectives. For example, an understanding of physiological mechanisms can help in determining whether a particular pattern of phenotypic variation or co-variation (such as an allometric relationship) represents what could possibly exist or just what selection has allowed.[2][17][18] Similarly, a thorough knowledge of physiological mechanisms can greatly enhance understanding of possible reasons for evolutionary correlations and constraints than is possible for many of the traits typically studied by evolutionary biologists (such as morphology).

performance as a central phenotype (e.g., measures of speed or stamina in animal locomotion)

Organismal

Role of in physiological evolution

behavior

Physiological and basis of variation in life history traits (e.g., clutch size)

endocrinological

Functional significance of

molecular evolution

basis of adaptation[19]

Genomic

Extent to which species differences are adaptive

Physiological underpinnings of limits to

geographic ranges

in physiology[20]

Geographic variation

Role of in shaping physiological evolution

sexual selection

Magnitude of "phylogenetic signal" in physiological traits

Role of and parasites in physiological evolution and immunity

pathogens

Application of to elucidate the degree of adaptation

optimality modeling

Role of in accounting for individual, population, and species differences[21]

phenotypic plasticity

Mechanistic basis of and constraints on evolution (e.g., putative Carrier's constraint on running and breathing)

trade-offs

Limits on sustained metabolic rate

[22]

Origin of scaling relations or allometric laws (and the so-called metabolic theory of ecology)

allometric

(see also Individual differences psychology)

Individual variation

Functional significance of biochemical

polymorphisms

Analysis of physiological variation via

quantitative genetics

Paleophysiology and the evolution of endothermy[24][25]

[23]

adaptational physiology

Human

Darwinian medicine

Evolution of dietary antioxidants

Important areas of current research include:

and manipulations[2]

Genetic analyses

Measurement of selection in the wild

[28]

and manipulation[2]

Phenotypic plasticity

[29]

Phylogenetically based comparisons

measurements of free-living energy demands of animals

Doubly labeled water

American Physiological Society "integrating the life sciences from molecule to organism"

Society for Integrative and Comparative Biology

Society for Experimental Biology

In the United States, research in evolutionary physiology is funded mainly by the National Science Foundation. A number of scientific societies feature sections that encompass evolutionary physiology, including:

American Naturalist

Comparative Biochemistry and Physiology

Comprehensive Physiology

Ecology

Archived 2006-04-25 at the Wayback Machine

Evolution

Functional Ecology

Integrative and Comparative Biology

Journal of Comparative Physiology

Journal of Evolutionary Biochemistry and Physiology

Journal of Evolutionary Biology

Journal of Experimental Biology

(formerly Physiological and Biochemical Zoology)

Ecological and Evolutionary Physiology

People, Labs, and Programs in Evolutionary Physiology

Evolutionary Systems Biology - Some Important Papers

Physiological and Biochemical Zoology Focused Collection: Trade-Offs in Ecological and Evolutionary Physiology