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Stroke

Stroke (also known as a cerebrovascular accident (CVA) or brain attack) is a medical condition in which poor blood flow to the brain causes cell death.[5] There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding.[5] Both cause parts of the brain to stop functioning properly.[5]

For other uses, see Stroke (disambiguation).

Stroke

Cerebrovascular accident (CVA), cerebrovascular insult (CVI), brain attack

Neurology, stroke medicine

Ischemic (blockage) and hemorrhagic (bleeding)[5]

Based on symptoms with medical imaging typically used to rule out bleeding[9][10]

Based on the type[2]

Average life expectancy 1 year[2]

42.4 million (2015)[11]

6.3 million (2015)[12]

Signs and symptoms of stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, dizziness, or loss of vision to one side.[2][3] Signs and symptoms often appear soon after the stroke has occurred.[3] If symptoms last less than one or two hours, the stroke is a transient ischemic attack (TIA), also called a mini-stroke.[3] Hemorrhagic stroke may also be associated with a severe headache.[3] The symptoms of stroke can be permanent.[5] Long-term complications may include pneumonia and loss of bladder control.[3]


The biggest risk factor for stroke is high blood pressure.[7] Other risk factors include high blood cholesterol, tobacco smoking, obesity, diabetes mellitus, a previous TIA, end-stage kidney disease, and atrial fibrillation.[2][7][8] Ischemic stroke is typically caused by blockage of a blood vessel, though there are also less common causes.[13][14][15] Hemorrhagic stroke is caused by either bleeding directly into the brain or into the space between the brain's membranes.[13][16] Bleeding may occur due to a ruptured brain aneurysm.[13] Diagnosis is typically based on a physical exam and supported by medical imaging such as a CT scan or MRI scan.[9] A CT scan can rule out bleeding, but may not necessarily rule out ischemia, which early on typically does not show up on a CT scan.[10] Other tests such as an electrocardiogram (ECG) and blood tests are done to determine risk factors and rule out other possible causes.[9] Low blood sugar may cause similar symptoms.[9]


Prevention includes decreasing risk factors, surgery to open up the arteries to the brain in those with problematic carotid narrowing, and warfarin in people with atrial fibrillation.[2] Aspirin or statins may be recommended by physicians for prevention.[2] Stroke is a medical emergency.[5] Ischemic strokes, if detected within three to four-and-a-half hours, may be treatable with medication that can break down the clot,[2] while hemorrhagic strokes sometimes benefit from surgery.[2] Treatment to attempt recovery of lost function is called stroke rehabilitation, and ideally takes place in a stroke unit; however, these are not available in much of the world.[2]


In 2023, 15 million people worldwide had a stroke.[17] In 2015, there were about 42.4 million people who had previously had stroke and were still alive.[11] Between 1990 and 2010 the annual incidence of stroke decreased by approximately 10% in the developed world, but increased by 10% in the developing world.[18] In 2015, stroke was the second most frequent cause of death after coronary artery disease, accounting for 6.3 million deaths (11% of the total).[12] About 3.0 million deaths resulted from ischemic stroke while 3.3 million deaths resulted from hemorrhagic stroke.[12] About half of people who have had stroke live less than one year.[2] Overall, two thirds of cases of stroke occurred in those over 65 years old.[18]

which is bleeding within the brain itself (when an artery in the brain bursts, flooding the surrounding tissue with blood), due to either intraparenchymal hemorrhage (bleeding within the brain tissue) or intraventricular hemorrhage (bleeding within the brain's ventricular system).

Intracerebral hemorrhage

which is bleeding that occurs outside of the brain tissue but still within the skull, and precisely between the arachnoid mater and pia mater (the delicate innermost layer of the three layers of the meninges that surround the brain).

Subarachnoid hemorrhage

numbness

reduction in sensory or vibratory sensation

initial (reduced muscle tone), replaced by spasticity (increased muscle tone), excessive reflexes, and obligatory synergies.[43]

flaccidity

Large vessel disease involves the and internal carotid arteries, the vertebral artery, and the Circle of Willis.[46] Diseases that may form thrombi in the large vessels include (in descending incidence): atherosclerosis, vasoconstriction (tightening of the artery), aortic, carotid or vertebral artery dissection, various inflammatory diseases of the blood vessel wall (Takayasu arteritis, giant cell arteritis, vasculitis), noninflammatory vasculopathy, Moyamoya disease and fibromuscular dysplasia. Strokes caused by artery dissections are in the strictest sense not always caused by a 'defined disease state', such events can occur in very young people and can be caused by physical injury such as hyperextension of the neck area or often by other forms of trauma.[47]

common

involves the smaller arteries inside the brain: branches of the circle of Willis, middle cerebral artery, stem, and arteries arising from the distal vertebral and basilar artery.[48] Diseases that may form thrombi in the small vessels include (in descending incidence): lipohyalinosis (build-up of fatty hyaline matter in the blood vessel as a result of high blood pressure and aging) and fibrinoid degeneration (stroke involving these vessels is known as a lacunar stroke) and microatheroma (small atherosclerotic plaques).[49]

Small vessel disease

sensitivity

at Curlie

Stroke

Archived 2020-10-27 at the Wayback Machine

DRAGON Score for Post-Thrombolysis

Archived 2016-09-13 at the Wayback Machine

THRIVE score for stroke outcome

National Institute of Neurological Disorders and Stroke